Structure of PDB 5umd Chain Y

Receptor sequence
>5umdY (length=101) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
ARNPKCPRIVKSCHSKTLDKYGLIKYPLTSEKAMKKIEEINTLVFMCDKR
ANKKNIKKSVKNLFGIECDKVNVLNTLNGDKKAYVRLSGEHDALEVANKI
G
3D structure
PDB5umd Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
ChainY
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Y R89 N90 S117 K119 K123 I127 N139 K140 K141 K145 N159 V160 L161 N162 L164 K169 Y171 R173 R2 N3 S30 K32 K36 I40 N52 K53 K54 K58 N72 V73 L74 N75 L77 K82 Y84 R86
BS02 rna Y C100 K103 T104 R137 N142 C13 K16 T17 R50 N55
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5umd, PDBe:5umd, PDBj:5umd
PDBsum5umd
PubMed28288098
UniProtQ8IE82

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