Structure of PDB 4r18 Chain Y

Receptor sequence
>4r18Y (length=211) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
TTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAAD
CQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMI
CGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVE
DALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVK
EEEGSFNNVIG
3D structure
PDB4r18 Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.
ChainY
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D17 R19 K33 G47 S131 D168 S171
Catalytic site (residue number reindexed from 1) D16 R18 K32 G46 S130 D167 S170
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ABA Y T2 D17 K33 G130 S131 Y170 S171 T1 D16 K32 G129 S130 Y169 S170
BS02 MG Y A165 D168 A169 S171 A164 D167 A168 S170
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Cellular Component
External links
PDB RCSB:4r18, PDBe:4r18, PDBj:4r18
PDBsum4r18
PubMed25244435
UniProtP30656|PSB5_YEAST Proteasome subunit beta type-5 (Gene Name=PRE2)

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