Structure of PDB 4qz2 Chain Y

Receptor sequence
>4qz2Y (length=212) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTIAGGAA
DCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTM
ICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSV
EDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV
KEEEGSFNNVIG
3D structure
PDB4qz2 Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914.
ChainY
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T1 D17 R19 K33 G47 S131 D168 S171
Catalytic site (residue number reindexed from 1) T1 D17 R19 K33 G47 S131 D168 S171
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 04C Y T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 A20 T21 V31 K33 G47 G48 A49 Y170
BS02 MG Y A165 D168 A169 S171 A165 D168 A169 S171
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:4qz2, PDBe:4qz2, PDBj:4qz2
PDBsum4qz2
PubMed25599643
UniProtP30656|PSB5_YEAST Proteasome subunit beta type-5 (Gene Name=PRE2)

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