Structure of PDB 3n5n Chain Y

Receptor sequence
>3n5nY (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
SSYHLFRDVAEVTAFRGSLLSWYDQEKRDLPWRRRAEDEMDLDRRAYAVW
VSEVMLQQTQVATVINYYTGWMQKWPTLQDLASASLEEVNQLWAGLGYYS
RGRRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFGQA
TGVVDGNVARVLCRVRAIGADPSSTLVSQQLWGLAQQLVDPARPGDFNQA
AMELGATVCTPQRPLCSQCPVESLCRARQRVEQEQLLASGSLSVEECAPN
TGQCHLCLPPSEPWDQTLGVVN
3D structure
PDB3n5n A structural hinge in eukaryotic MutY homologues mediates catalytic activity and Rad9-Rad1-Hus1 checkpoint complex interactions.
ChainY
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y204 D222
Catalytic site (residue number reindexed from 1) Y137 D155
Enzyme Commision number 3.2.2.31: adenine glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 Y R231 C276 C283 C286 C292 R295 R164 C209 C216 C219 C225 R228
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3n5n, PDBe:3n5n, PDBj:3n5n
PDBsum3n5n
PubMed20816984
UniProtQ9UIF7|MUTYH_HUMAN Adenine DNA glycosylase (Gene Name=MUTYH)

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