Structure of PDB 6zsc Chain XM

Receptor sequence

>6zscXM (length=287) Species: 9606 (Homo sapiens)

ARALDLLRGLPRVSLANLKPNPGSKKPERRPRGRRRGRKCGRGHKGERQR
GTRPRLGFEGGQTPFYIRIPKYGFNEGHSFRRQYKPLSLNRLQYLIDLGR
VDPSQPIDLTQLVNGRGVTIQPLKRDYGVQLVEEGADTFTAKVNIEVQLA
SELAIAAIEKNGGVVTTAFYDPRSLDIVCKPVPFFLRGQPIPKRMLPPEE
LVPYYTDAKNRGYLADPAKFPEARLELARKYGYILPDITKDELFKMLCTR
KDPRQIFFGLAPGWVVNMADKKILKPTDENLLKYYTS

3D structure

• PDB: 6zsc Structural basis of mitochondrial translation.
• Chain: XM
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	XM	L24 A25 L27 K28 N30 G32 K35 E37 R38 R39 P40 R41 G42 R43 R44 G46 R47 K48 C49 G50 R51 H53 K54 G55 E56 R57 Q58 R59 T61 R62 R64 F67 E68 G69 G70 Q71 T72 I76 R77 K80 H87 S88 T128 Q130 L132 K133 R196	L15 A16 L18 K19 N21 G23 K26 E28 R29 R30 P31 R32 G33 R34 R35 G37 R38 K39 C40 G41 R42 H44 K45 G46 E47 R48 Q49 R50 T52 R53 R55 F58 E59 G60 G61 Q62 T63 I67 R68 K71 H78 S79 T119 Q121 L123 K124 R187
BS02	MG	XM	R43 R44 R45	R34 R35 R36

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation
• GO:1990830 cellular response to leukemia inhibitory factor

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zsc, PDBe:6zsc, PDBj:6zsc
• PDBsum: 6zsc
• PubMed: 32812867
• UniProt: Q9P015|RM15_HUMAN Large ribosomal subunit protein uL15m (Gene Name=MRPL15)