Structure of PDB 6zsa Chain XM

Receptor sequence

>6zsaXM (length=287) Species: 9606 (Homo sapiens)

ARALDLLRGLPRVSLANLKPNPGSKKPERRPRGRRRGRKCGRGHKGERQR
GTRPRLGFEGGQTPFYIRIPKYGFNEGHSFRRQYKPLSLNRLQYLIDLGR
VDPSQPIDLTQLVNGRGVTIQPLKRDYGVQLVEEGADTFTAKVNIEVQLA
SELAIAAIEKNGGVVTTAFYDPRSLDIVCKPVPFFLRGQPIPKRMLPPEE
LVPYYTDAKNRGYLADPAKFPEARLELARKYGYILPDITKDELFKMLCTR
KDPRQIFFGLAPGWVVNMADKKILKPTDENLLKYYTS

3D structure

• PDB: 6zsa Structural basis of mitochondrial translation.
• Chain: XM
• Resolution: 4.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	XM	L24 A25 N30 G32 S33 K34 K35 E37 R38 R39 P40 R41 G42 R44 G46 R47 K48 C49 G50 R51 H53 K54 G55 E56 R57 Q58 R59 T61 R62 R64 F67 G69 G70 Q71 T72 F74 I76 R77 P79 K80 H87 S88 R100 Y103 T128 Q130 L132 K133 K189 R196	L15 A16 N21 G23 S24 K25 K26 E28 R29 R30 P31 R32 G33 R35 G37 R38 K39 C40 G41 R42 H44 K45 G46 E47 R48 Q49 R50 T52 R53 R55 F58 G60 G61 Q62 T63 F65 I67 R68 P70 K71 H78 S79 R91 Y94 T119 Q121 L123 K124 K180 R187
BS02	MG	XM	G42 R43 R44 R45	G33 R34 R35 R36

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation
• GO:1990830 cellular response to leukemia inhibitory factor

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zsa, PDBe:6zsa, PDBj:6zsa
• PDBsum: 6zsa
• PubMed: 32812867
• UniProt: Q9P015|RM15_HUMAN Large ribosomal subunit protein uL15m (Gene Name=MRPL15)