Structure of PDB 7aoi Chain XL

Receptor sequence

>7aoiXL (length=521) Species: 5691 (Trypanosoma brucei)

SFNLPRERQILGGLHADWRTQMKRSGSILNDITPALPDTKRTEEQRRRVA
GWRPVVKLLGDQRLRIAIVGRMNSGKSSLFNLLRLEPTVPGRSNVVRDFD
GITRDSVEGQAQLEGMHFTIIDTPGMVQGRMVEEAFRTVETADAAIFVTA
VDEDIMPEELSLMQYLHLKHMPVVLLANKMDLIQEEEEEAVLDRYNSLGF
GNAIPFSARRKSGLEMLAAVLEPLYHIHAMHKVENDWDIEDLAMQGDESA
MEEIRERNCSDRFIRIAIVGRTNSGKSSLVNRLVGFERNRAVDEKNSTRD
PVELPCSYKGRKLKLIDTAGLARHRYRADRDFIGRIHGLSVNEIRFAHVV
IVVFDATEGHPNKYDMAVLHSVAAEGRPFLLCANKWDAVLDQSATAEAID
FKIKRQVREVKYSNAVVVSAHTGLNLTLLMDQALELYDKWNKRVRRAELT
RLWRKMEKSVVARIGRITQVNTRPPTFLLQLQTKNDSNTLPKALQEMMKN
TLVEEFDFRGVPIRLIQEVKD

3D structure

• PDB: 7aoi Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit.
• Chain: XL
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	XL	E130 P131 P134 T316 K339 R367 H368 R369 Y370 R374 R389 K407 A411 H414 K545	E86 P87 P90 T272 K295 R323 H324 R325 Y326 R330 R345 K363 A367 H370 K492
BS02	GTP	XL	M116 N117 G119 K120 S121 S122 V140 R141 D142 G145 I146 T147 N222 K223 D225 L226 S251 A252 R253	M72 N73 G75 K76 S77 S78 V96 R97 D98 G101 I102 T103 N178 K179 D181 L182 S207 A208 R209
BS03	GTP	XL	T316 N317 G319 K320 S321 S322 A335 S341 T342 N428 K429 D431 S463 A464 H465	T272 N273 G275 K276 S277 S278 A291 S297 T298 N384 K385 D387 S419 A420 H421

Gene Ontology

Molecular Function

• GO:0005525 GTP binding

External links

• PDB: RCSB:7aoi, PDBe:7aoi, PDBj:7aoi
• PDBsum: 7aoi
• PubMed: 33576519
• UniProt: C9ZS56