Structure of PDB 7aoi Chain XB

Receptor sequence

>7aoiXB (length=614) Species: 5691 (Trypanosoma brucei) [Search protein sequence]

VPQQLKAYGGTFSRSVGERSNHLVSDVVLQSLSPSSTHNSPLLSKNIKTK
TVTSFEDMPLYPELRSALRQLRITTPSPIQQSAVEVIMQRKDTVVAAPHG
EGKTLAYLLPLYQNMIKDRDVYKIPLRERRPRMILLAPTRELIAQLHHVC
SVLGEATGLHAISFTSRKRANHRLSRLLKQQLVDVMIMDPKIVLRLIRAR
RVFLDDLRYVAVDEADGMLSSQHDHDAVHLLMKVQKRVMFKHLWPVQTQT
VFATAFITRKLEFVVGKKYPDAVTCIRRQRMHRPPGTLRHRFLPVERERE
KMDTLQHLLKKHGNRPREILTDIEEEQAYSKPHYLSGSLEELVELDEMKE
RVRHALEGVRPVHWGHLTTVAAPFTCHVPRTVFADGKRCIIFTRGIDCAT
AVYHRLRGCGYTCSLLHAALPAAVRRRMFADFASGRTNILCSTDVAARGL
DLHVDFVVNFDMPTNALTYLSRAGRTARQGRLGQVYSLYTKRQGVIVSAV
RAFLQKQLPLEGISNWKRHMMEPRYAEWRTHKLNAIARSYVSLITQKTIP
AHLERTYLRHNATWRPLFHPQTTGVHGGVPPRQQQRVMDAITWKAVCFRR
GLLARRKGGRAKFG

3D structure

PDB

7aoi Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit.

Chain

Resolution

3.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	XB	K52 A53 Y54 G55 R60 V62 V70 S71 V73 S79 P80 S81 N92 I93 K94 K96 Q135 K137 P184 R186 S212 R213 K214 R215 N217 H218 R219 S221 K225 D235 K237 R241 R244 R246 R247 S267 Q268 H269 D270 H271 V274 M278 K282 R305 K306 F309 V310 K314 R343 E344 R345 R491 G492 I493 D494 C495 A498 H501 R502 H514 A515 A516 L517 P518 R522 T540 V542 F557 T561 K588 R589 G591 V592 Q602 N612 W613 K614 R621 Y622 A623 E624 W625 R626 T627 H628 L630 R635 V638 Q643 K644 H649 L650 R652 T653 Y654 R656 H657 N658 T660 R662 P663 F665 H666 P667 Q668 T669 H673 P678 R679 Q680 R683 V684 I688 R696 R697 R703 K704 A708 K709 F710	K6 A7 Y8 G9 R14 V16 V24 S25 V27 S33 P34 S35 N46 I47 K48 K50 Q89 K91 P138 R140 S166 R167 K168 R169 N171 H172 R173 S175 K179 D189 K191 R195 R198 R200 R201 S221 Q222 H223 D224 H225 V228 M232 K236 R259 K260 F263 V264 K268 R297 E298 R299 R394 G395 I396 D397 C398 A401 H404 R405 H417 A418 A419 L420 P421 R425 T443 V445 F460 T464 K491 R492 G494 V495 Q505 N515 W516 K517 R524 Y525 A526 E527 W528 R529 T530 H531 L533 R538 V541 Q546 K547 H552 L553 R555 T556 Y557 R559 H560 N561 T563 R565 P566 F568 H569 P570 Q571 T572 H576 P581 R582 Q583 R586 V587 I591 R599 R600 R606 K607 A611 K612 F613
BS02	ADP	XB	I119 T121 Q126 H145 G146 G148 K149 T150 A469 D548 R575 Q576	I73 T75 Q80 H99 G100 G102 K103 T104 A372 D451 R478 Q479

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:7aoi, PDBe:7aoi, PDBj:7aoi
PDBsum	7aoi
PubMed	33576519
UniProt	D0A9G9

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