Structure of PDB 8xej Chain X

Receptor sequence
>8xejX (length=358) Species: 9606 (Homo sapiens) [Search protein sequence]
GALLRDLVLGVLGTAAFLLDLGTDLWAAVQYALGGRYLWAALVLALLGLA
SVALQLFSWLWLRADPAGLHGSQPPRRCLALLHLLQLGYLYRCVQELRQG
LLVWQQEEPSEFDLAYADFLALDISMLRLFETFLETAPQLTLVLAIMLQS
GRAEYYQWVGICTSFLGISWALLDYHRALRTCLPSKPLLGLGSSVIYFLW
NLLLLWPRVLAVALFSALFPSYVALHFLGLWLVLLLWVWLQGTDFMPDPS
SEWLYRVTVATILYFSWFNVAEGRTRGRAIIHFAFLLSDSILLVATWVTH
SSWLPSGIPLQLWLPVGCGCFFLGLALRLVYYHWLHPSCCWLPQNRRMTH
LAQKFFPK
3D structure
PDB8xej The role of the C-terminal tail region as a plug to regulate XKR8 lipid scramblase.
ChainX
Resolution3.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DLP X L44 I152 Q155 S222 P226 V229 F233 L38 I146 Q149 S216 P220 V223 F227
Gene Ontology
Molecular Function
GO:0017128 phospholipid scramblase activity
Biological Process
GO:0002513 tolerance induction to self antigen
GO:0006915 apoptotic process
GO:0043652 engulfment of apoptotic cell
GO:0045663 positive regulation of myoblast differentiation
GO:0051649 establishment of localization in cell
GO:0070782 phosphatidylserine exposure on apoptotic cell surface
GO:0097350 neutrophil clearance
GO:1902742 apoptotic process involved in development
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
GO:0071944 cell periphery

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xej, PDBe:8xej, PDBj:8xej
PDBsum8xej
PubMed38364890
UniProtQ9H6D3|XKR8_HUMAN XK-related protein 8 (Gene Name=XKR8)

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