Structure of PDB 8qfd Chain X

Receptor sequence

>8qfdX (length=118) Species: 9606 (Homo sapiens) [Search protein sequence]

KIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAMK
KIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYV
RLAPDYDALDVANKIGII

3D structure

PDB

8qfd The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons

Chain

Resolution

2.2 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	X	F46 R47 R48 P49 T51 R53 R56 Q57 K59 Y60 R62 T83 S85 K89 N105 K106 H107 K123 N125 T126 I128 P130 K134 K135 Y137 R139	F8 R9 R10 P11 T13 R15 R18 Q19 K21 Y22 R24 T45 S47 K51 N67 K68 H69 K85 N87 T88 I90 P92 K96 K97 Y99 R101
BS02	rna	X	P49 T51 R56 K63 P66 R68 K70 H107 Q108	P11 T13 R18 K25 P28 R30 K32 H69 Q70

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding
GO:0045296	cadherin binding
GO:1904841	TORC2 complex binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8qfd, PDBe:8qfd, PDBj:8qfd
PDBsum	8qfd
PubMed	38383789
UniProt	P62750\|RL23A_HUMAN Large ribosomal subunit protein uL23 (Gene Name=RPL23A)