Structure of PDB 8gbj Chain X

Receptor sequence
>8gbjX (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
RSSLKEIEPNLFADGDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEV
EVLFIDTDYHFDMLRLVTILEHRLSQSSEEIIKYCLGRFFLVYCSSSTHL
LLTLYSLESMFCSHPSLCLLILDSLSAFYWIDRVNGGESVNLQESTLRKC
SQCLEKLVNDYRLVLFATTQTIMQKAIDYRPYLCKAWQQLVKHRMFFSKQ
DSNQFSLVSRCLKSNSLKKHFFIIGESGVEFC
3D structure
PDB8gbj Structural insights into BCDX2 complex function in homologous recombination.
ChainX
Resolution3.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna X W156 R159 M199 Q200 R224 W130 R133 M173 Q174 R180
BS02 ANP X E50 G51 T52 G53 K54 T55 E56 R91 I272 G273 E274 E24 G25 T26 G27 K28 T29 E30 R65 I224 G225 E226
Gene Ontology
Molecular Function
GO:0000400 four-way junction DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0000724 double-strand break repair via homologous recombination
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006974 DNA damage response
GO:0007098 centrosome cycle
GO:0010165 response to X-ray
GO:0010332 response to gamma radiation
GO:0022008 neurogenesis
GO:0035264 multicellular organism growth
GO:0042148 DNA strand invasion
GO:0043524 negative regulation of neuron apoptotic process
GO:0050769 positive regulation of neurogenesis
GO:0051321 meiotic cell cycle
GO:2000269 regulation of fibroblast apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005856 cytoskeleton
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Cellular Component
External links
PDB RCSB:8gbj, PDBe:8gbj, PDBj:8gbj
PDBsum8gbj
PubMed37344589
UniProtO43543|XRCC2_HUMAN DNA repair protein XRCC2 (Gene Name=XRCC2)

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