Structure of PDB 8g8e Chain X

Receptor sequence
>8g8eX (length=140) Species: 9606 (Homo sapiens) [Search protein sequence]
KALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEA
LQLSFKNMCKLRPLLQKWVEEADNNENLQEIRKRKRTSIENRVRGNLENL
FLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRS
3D structure
PDB8g8e Histone modifications regulate pioneer transcription factor cooperativity.
ChainX
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna X F179 S180 T182 T183 N196 R234 K286 F40 S41 T43 T44 N57 R86 K138
BS02 dna X R157 T163 Q164 C185 R232 K233 R234 T235 I237 V273 V276 W277 N280 R18 T24 Q25 C46 R84 K85 R86 T87 I89 V125 V128 W129 N132
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0035198 miRNA binding
GO:0043565 sequence-specific DNA binding
GO:1990837 sequence-specific double-stranded DNA binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001714 endodermal cell fate specification
GO:0001824 blastocyst development
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0009611 response to wounding
GO:0009653 anatomical structure morphogenesis
GO:0009786 regulation of asymmetric cell division
GO:0010468 regulation of gene expression
GO:0035019 somatic stem cell population maintenance
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:1902894 negative regulation of miRNA transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8g8e, PDBe:8g8e, PDBj:8g8e
PDBsum8g8e
PubMed37225990
UniProtQ01860|PO5F1_HUMAN POU domain, class 5, transcription factor 1 (Gene Name=POU5F1)

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