Structure of PDB 8esr Chain X

Receptor sequence

>8esrX (length=132) Species: 4896 (Schizosaccharomyces pombe)

SVAKAKGAQKTVQKGIHNSTTFRRPKTLQLSRKPKYARKSVAHAPRLDEY
KIIVNPINSESAMKKIEDDNTLVFHVHLKANKFTIKEAVRKLYSVEPVKI
NTLIRPNGTKKAFVKLSADADALDVANRIGFL

3D structure

• PDB: 8esr Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Chain: X
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	X	S28 T30 R32 R33 P34 K35 Q38 L39 R41 K42 P43 K44 Y45 R47 S68 K74 D78 N90 K91 F92 K108 N110 T111 I113 P115 K119 K120 F122 K124	S19 T21 R23 R24 P25 K26 Q29 L30 R32 K33 P34 K35 Y36 R38 S59 K65 D69 N81 K82 F83 K99 N101 T102 I104 P106 K110 K111 F113 K115
BS02	rna	X	I17 H18 P34 T36 L37 R41 K48 H52 R55 F92 R99 E105	I16 H17 P25 T27 L28 R32 K39 H43 R46 F83 R90 E96
BS03	peptide	X	L87 I113 N116 G117	L78 I104 N107 G108

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0180023 cytosolic large ribosomal subunit assembly

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8esr, PDBe:8esr, PDBj:8esr
• PDBsum: 8esr
• PubMed: 36423630
• UniProt: Q10330|RL25A_SCHPO Large ribosomal subunit protein uL23A (Gene Name=rpl2501)