Structure of PDB 7wtv Chain X

Receptor sequence

>7wtvX (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]

GKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIV
LEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVL
VAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPR

3D structure

PDB

7wtv The nucleoplasmic phase of pre-40S formation prior to nuclear export.

Chain

Resolution

3.5 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	X	G2 K3 C4 R5 G6 R8 T9 R11 K12 H16 R17 R18 Q20 W22 H23 D24 A30 A38 A44 S45 H46 K48 K76 G104 R107 K108 H110 R119 K121 K124 S129 Y134 K137	G1 K2 C3 R4 G5 R7 T8 R10 K11 H15 R16 R17 Q19 W21 H22 D23 A29 A37 A43 S44 H45 K47 K75 G103 R106 K107 H109 R118 K120 K123 S128 Y133 K136

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0034063	stress granule assembly
GO:0042274	ribosomal small subunit biogenesis
GO:1990145	maintenance of translational fidelity

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0032040	small-subunit processome
GO:0045202	synapse
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:7wtv, PDBe:7wtv, PDBj:7wtv
PDBsum	7wtv
PubMed	36321656
UniProt	P62266\|RS23_HUMAN Small ribosomal subunit protein uS12 (Gene Name=RPS23)