Structure of PDB 7t7q Chain X

Receptor sequence
>7t7qX (length=157) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
TLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESI
GKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEE
MIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHT
FLHLIRK
3D structure
PDB7t7q Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus.
ChainX
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDW X I14 G15 N18 G43 R44 K45 T46 L62 T63 S64 G94 Q95 T96 E100 T121 I14 G15 N18 G43 R44 K45 T46 L62 T63 S64 G94 Q95 T96 E100 T121
BS02 06U X L5 V6 A7 Q19 D27 L28 V31 I50 F92 L5 V6 A7 Q19 D27 L28 V31 I50 F92
Gene Ontology
Molecular Function
GO:0004146 dihydrofolate reductase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0046452 dihydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:7t7q, PDBe:7t7q, PDBj:7t7q
PDBsum7t7q
PubMed35143481
UniProtP0A017|DYR_STAAU Dihydrofolate reductase (Gene Name=folA)

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