Structure of PDB 6xsw Chain X

Receptor sequence
>6xswX (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
CPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRL
FNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQ
GCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLS
AILRTSLRFRLDAHGQAMVFPYHRPEVIGSVVMLEIDNRLCLQSPDHCFP
DAQSAADYLGALSAVERLDFPYPLRDVRGEP
3D structure
PDB6xsw NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells.
ChainX
Resolution2.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA X K1396 D1399 R1401 D1403 D1414 D1417 K9 D12 R14 D16 D27 D30
BS02 CA X H1479 D1482 R1484 D1486 D1497 D1500 H92 D95 R97 D99 D110 D113
BS03 CA X L1437 N1440 R1442 D1444 D1455 D1458 L50 N53 R55 D57 D68 D71
BS04 CA X C1476 C1489 C1494 D1497 C89 C102 C107 D110
Gene Ontology
Biological Process
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
GO:0030154 cell differentiation
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:6xsw, PDBe:6xsw, PDBj:6xsw
PDBsum6xsw
PubMed34095881
UniProtQ9UM47|NOTC3_HUMAN Neurogenic locus notch homolog protein 3 (Gene Name=NOTCH3)

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