Structure of PDB 6xk9 Chain X

Receptor sequence
>6xk9X (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]
GPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSD
DVETDTVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVI
IEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQ
DQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLV
3D structure
PDB6xk9 CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.
ChainX
Resolution3.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V4M X V535 K571 S573 G574 I625 G626 K627 V99 K135 S137 G138 I189 G190 K191
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:6xk9, PDBe:6xk9, PDBj:6xk9
PDBsum6xk9
PubMed33197925
UniProtP15170|ERF3A_HUMAN Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Gene Name=GSPT1)

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