Structure of PDB 6kkb Chain X

Receptor sequence
>6kkbX (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIKVDLE
AFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRA
AVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDD
TEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHF
WPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE
3D structure
PDB6kkb Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance.
ChainX
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide X K288 E299 I302 K306 L454 E457 K71 E82 I85 K89 L237 E240
BS02 8HO X F269 F272 I275 I276 R282 M313 R316 L330 F52 F55 I58 I59 R65 M96 R99 L113
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6kkb, PDBe:6kkb, PDBj:6kkb
PDBsum6kkb
PubMed31655060
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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