Structure of PDB 5fmg Chain X

Receptor sequence
>5fmgX (length=191) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
GCVLGMSGSNCVAIACDLRLGANTFTTVSTKFSKIFKMNNNVYVGLSGLA
TDIQTLYEILRYRVNLYEVRQDAEMDVECFANMLSSILYSNRFSPYFVNP
IVVGFKYEPYLTAYDLIGAKCETRDFVVNGVTSEQLFGMCESLYVKDQDE
NGLFETISQCLLSALDRDCISGWGAEVLVLTPEKIIKKKLK
3D structure
PDB5fmg Structure and Function Based Design of Plasmodium-Selective Proteasome Inhibitors
ChainX
Resolution3.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7F1 X A136 D138 I140 C144 A113 D115 I117 C121
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0019774 proteasome core complex, beta-subunit complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5fmg, PDBe:5fmg, PDBj:5fmg
PDBsum5fmg
PubMed26863983
UniProtQ8I261

[Back to BioLiP]