Structure of PDB 4hup Chain X

Receptor sequence
>4hupX (length=263) Species: 3988 (Ricinus communis) [Search protein sequence]
QYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPIN
QRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAI
THLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYY
STGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSV
ITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIAL
MVYRCAPPPSSQF
3D structure
PDB4hup Peptide-conjugated pterins as inhibitors of ricin toxin A.
ChainX
Resolution1.699 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V81
Catalytic site (residue number reindexed from 1) V77
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 19M X Y80 V81 G121 N122 Y123 I172 S176 R180 N209 W211 Y76 V77 G117 N118 Y119 I168 S172 R176 N205 W207 MOAD: ic50=15uM
PDBbind-CN: -logKd/Ki=4.82,IC50=15uM
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

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Molecular Function
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Biological Process
External links
PDB RCSB:4hup, PDBe:4hup, PDBj:4hup
PDBsum4hup
PubMed23214944
UniProtP02879|RICI_RICCO Ricin

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