Structure of PDB 4g8z Chain X

Receptor sequence
>4g8zX (length=204) Species: 42068 (Pneumocystis jirovecii) [Search protein sequence]
QQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFSRVTSFVPTFDSFESM
NVVLMGRKTWESIPLQNRPLKGRINVVITRNAAAAAAAAIHSAKSLDHAL
ELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHC
DVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMW
TRDL
3D structure
PDB4g8z Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants.
ChainX
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TOP X I10 V11 A12 L25 E32 F36 S64 I123 I8 V9 A10 L23 E30 F34 S62 I121 MOAD: Ki=227nM
BindingDB: IC50=12000nM,Ki=280000nM
BS02 NDP X V11 A12 I19 N23 S24 L25 G58 R59 K60 T61 I80 T81 R82 K96 I123 G124 G125 A126 Q127 L128 V9 A10 I17 N21 S22 L23 G56 R57 K58 T59 I78 T79 R80 K94 I121 G122 G123 A124 Q125 L126
Gene Ontology
Molecular Function
GO:0004146 dihydrofolate reductase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0046452 dihydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005739 mitochondrion

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Cellular Component
External links
PDB RCSB:4g8z, PDBe:4g8z, PDBj:4g8z
PDBsum4g8z
PubMed23545530
UniProtP16184|DYR_PNECA Dihydrofolate reductase

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