Structure of PDB 3pb8 Chain X

Receptor sequence
>3pb8X (length=313) Species: 9606 (Homo sapiens) [Search protein sequence]
VPLIGSLPEARLRRVVGQLDPQRLWSTYLRPLLVVRTPGSPGNLQVRKFL
EATLRSLTAGWHVELDPFTASTPLGPVDFGNVVATLDPRAARHLTLACHY
DSKLFPPGSTPFVGATDSAVPCALLLELAQALDLELSRAKKQAAPVTLQL
LFLDGEEALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIELFMLLD
LLGAPNPTFYSHFPRTVRWFHRLRSIEKRLHRLNLLQSHPQEVMYFQPGE
PFGSVEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLC
RILAVFLAEYLGL
3D structure
PDB3pb8 Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding
ChainX
Resolution1.13 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.5: glutaminyl-peptide cyclotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AHN X D186 D269 E325 H351 D117 D200 E256 H282 MOAD: Ki=5.748uM
PDBbind-CN: -logKd/Ki=5.24,Ki=5.748uM
BS02 ZN X D186 E226 H351 D117 E157 H282
Gene Ontology
Molecular Function
GO:0016603 glutaminyl-peptide cyclotransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3pb8, PDBe:3pb8, PDBj:3pb8
PDBsum3pb8
PubMed21288892
UniProtQ9NXS2|QPCTL_HUMAN Glutaminyl-peptide cyclotransferase-like protein (Gene Name=QPCTL)

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