Structure of PDB 3pb7 Chain X

Receptor sequence
>3pb7X (length=309) Species: 9606 (Homo sapiens) [Search protein sequence]
GSLPEARLRRVVGQLDPQRLWSTYLRPLLVVRTPGSPGNLQVRKFLEATL
RSLTAGWHVELDPFTASTPLGPVDFGNVVATLDPRAARHLTLACHYDSKL
FPPGSTPFVGATDSAVPCALLLELAQALDLELSRAKKQAAPVTLQLLFLD
GEEALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIELFMLLDLLGA
PNPTFYSHFPRTVRWFHRLRSIEKRLHRLNLLQSHPQEVMYFQPGEPFGS
VEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLCRILA
VFLAEYLGL
3D structure
PDB3pb7 Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding
ChainX
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.5: glutaminyl-peptide cyclotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PBD X D186 E225 E226 W231 D269 V324 E325 F346 W350 H351 D113 E152 E153 W158 D196 V251 E252 F273 W277 H278 MOAD: Ki=1.817uM
PDBbind-CN: -logKd/Ki=5.74,Ki=1.817uM
BS02 ZN X D186 E226 H351 D113 E153 H278
Gene Ontology
Molecular Function
GO:0016603 glutaminyl-peptide cyclotransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3pb7, PDBe:3pb7, PDBj:3pb7
PDBsum3pb7
PubMed21288892
UniProtQ9NXS2|QPCTL_HUMAN Glutaminyl-peptide cyclotransferase-like protein (Gene Name=QPCTL)

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