Structure of PDB 3nzc Chain X

Receptor sequence
>3nzcX (length=206) Species: 4754 (Pneumocystis carinii) [Search protein sequence]
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFE
SMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDH
ALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDI
HCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFE
MWTRDL
3D structure
PDB3nzc Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5'-([omega]-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives
ChainX
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D2O X I10 V11 A12 L25 E32 I33 F36 P66 F69 I123 I10 V11 A12 L25 E32 I33 F36 P66 F69 I123 PDBbind-CN: -logKd/Ki=7.02,IC50=96nM
Gene Ontology
Molecular Function
GO:0004146 dihydrofolate reductase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0046452 dihydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005739 mitochondrion

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External links
PDB RCSB:3nzc, PDBe:3nzc, PDBj:3nzc
PDBsum3nzc
PubMed21206056
UniProtP16184|DYR_PNECA Dihydrofolate reductase

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