Structure of PDB 3myk Chain X

Receptor sequence
>3mykX (length=706) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]
NPIHDRTSDYHKYLKVKQGDSDLFKLTVSDKRYIWYNPDPKERDSYECGE
IVSETSDSFTFKTVDGQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPA
VFHNLRVRYNQDLIYTYSGLFLVAVNPFKRIPIYTQEMVDIFKGRRRNEV
APHIFAISDVAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAG
RNSGVLEQQILQANPILEAFGNAKTTRNNNASRFGKFIEIQFNSAGFISG
ASIQSYLLEKSRVVFQSETERNYHIFYQLLAGATAEEKKALHLAGPESFN
YLNQSGCVDIKGVSDSEEFKITRQAMDIVGFSQEEQMSIFKIIAGILHLG
NIKFEKGAGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLV
AQHLNVEKSSSSRDALVKALYGRLFLWLVKKINNVLCQERKAYFIGVLDI
SGFEIFKVNSFEQLCINYTNEKLQQFFNHHMFKLEQEEYLKEKINWTFID
FGLDSQATIDLIDGRQPPGILALLDEQSVFPNATDNTLITKLHSHFSKKN
AKYEEPRFSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFKDSSD
NVVTKLFNDPNIASRAKKGANFITVAAQYKEQLASLMATLETTNPHFVRC
IIPNNKQLPAKLEDKVVLDQLRCNGVLEGIRITRKGFPNRIIQYRFGITK
IFFRAG
3D structure
PDB3myk Insights into the importance of hydrogen bonding in the gamma-phosphate binding pocket of myosin: structural and functional studies of serine 236
ChainX
Resolution1.84 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S181 T186 A236 S237
Catalytic site (residue number reindexed from 1) S180 T185 A231 S232
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BIT X F239 G240 Y261 L262 L263 S456 C470 Y634 F234 G235 Y256 L257 L258 S451 C465 Y629 BindingDB: IC50=4900nM
BS02 MG X T186 S237 T185 S232
BS03 ANP X N127 P128 F129 K130 S181 G182 G184 K185 T186 E187 N233 A236 S237 G457 N126 P127 F128 K129 S180 G181 G183 K184 T185 E186 N228 A231 S232 G452
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:3myk, PDBe:3myk, PDBj:3myk
PDBsum3myk
PubMed20459085
UniProtP08799|MYS2_DICDI Myosin-2 heavy chain (Gene Name=mhcA)

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