Structure of PDB 3myh Chain X

Receptor sequence
>3myhX (length=708) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]
NPIHDRTSDYHKYLKVKQGDSDLFKLTVSDKRYIWYNPDPKERDSYECGE
IVSETSDSFTFKTVDGQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPA
VFHNLRVRYNQDLIYTYSGLFLVAVNPFKRIPIYTQEMVDIFKGRRRNEV
APHIFAISDVAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAG
RGVLEQQILQANPILEAFGNAKTTRNNNASRFGKFIEIQFNSAGFISGAS
IQSYLLEKSRVVFQSETERNYHIFYQLLAGATAEEKKALHLAGPESFNYL
NQSGCVDIKGVSDSEEFKITRQAMDIVGFSQEEQMSIFKIIAGILHLGNI
KFEKGAGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLVAQ
HLNVEKSSSSRDALVKALYGRLFLWLVKKINNVLCQERKAYFIGVLDISG
FEIFKVNSFEQLCINYTNEKLQQFFNHHMFKLEQEEYLKEKINWTFIDFG
LDSQATIDLIDGRQPPGILALLDEQSVFPNATDNTLITKLHSHFSKKNAK
YEEPRFSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFKDSSDNV
VTKLFNDPNIASRAKKGANFITVAAQYKEQLASLMATLETTNPHFVRCII
PNNKQLPAKLEDKVVLDQLRCNGVLEGIRITRKGFPNRIIYADDPEQYRF
GITKIFFR
3D structure
PDB3myh Insights into the importance of hydrogen bonding in the gamma-phosphate binding pocket of myosin: structural and functional studies of serine 236
ChainX
Resolution2.01 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S181 T186 A236 S237
Catalytic site (residue number reindexed from 1) S180 T185 A229 S230
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG X T186 S237 T185 S230
BS02 VO4 X S181 G182 K185 N233 A236 S237 G457 S180 G181 K184 N226 A229 S230 G450
BS03 ADP X N127 P128 F129 K130 G182 G184 K185 T186 E187 N233 N126 P127 F128 K129 G181 G183 K184 T185 E186 N226
BS04 BIT X F239 G240 Y261 L262 L263 S456 C470 Y634 F232 G233 Y254 L255 L256 S449 C463 Y627 BindingDB: IC50=4900nM
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

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Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:3myh, PDBe:3myh, PDBj:3myh
PDBsum3myh
PubMed20459085
UniProtP08799|MYS2_DICDI Myosin-2 heavy chain (Gene Name=mhcA)

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