Structure of PDB 3lju Chain X

Receptor sequence
>3ljuX (length=373) Species: 9606 (Homo sapiens) [Search protein sequence]
SGRENLYFQGKERRRAVLELLQRPGNARCADCGAPDPDWASYTLGVFICL
SCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSF
YYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRD
NGQFLSRKFVLTEREGALKYFNEPKAVMKIEHLNATFQPAKIGHPHGLQV
TYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGASDADLVP
KLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEV
FIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREW
VAAFQKAVDRPMLPQEYAVEAHF
3D structure
PDB3lju Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
ChainX
Resolution1.702 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN X C21 C24 C41 C44 C29 C32 C49 C52
BS02 IP9 X K261 P264 R271 R273 Y284 R332 K264 P267 R274 R276 Y287 R335
BS03 IP9 X K138 R141 R149 Y162 N164 K172 R206 K146 R149 R157 Y170 N172 K175 R209
Gene Ontology
Molecular Function
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding
GO:0046872 metal ion binding
GO:1902936 phosphatidylinositol bisphosphate binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3lju, PDBe:3lju, PDBj:3lju
PDBsum3lju
PubMed21057110
UniProtO75689|ADAP1_HUMAN Arf-GAP with dual PH domain-containing protein 1 (Gene Name=ADAP1)

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