Structure of PDB 3kwb Chain X

Receptor sequence
>3kwbX (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
APDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSP
QNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNP
TGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVY
YDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNK
NNACGIANLASFPKM
3D structure
PDB3kwb Dioxo-triazines as a novel series of cathepsin K inhibitors
ChainX
Resolution2.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.38: cathepsin K.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ORH X G1023 C1025 Y1067 A1134 A1137 S1138 L1160 N1161 L1209 G23 C25 Y67 A134 A137 S138 L160 N161 L209 PDBbind-CN: -logKd/Ki=7.77,IC50=17nM
BindingDB: IC50=17nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3kwb, PDBe:3kwb, PDBj:3kwb
PDBsum3kwb
PubMed20153187
UniProtP43235|CATK_HUMAN Cathepsin K (Gene Name=CTSK)

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