Structure of PDB 3i39 Chain X

Receptor sequence

>3i39X (length=635) Species: 246194 (Carboxydothermus hydrogenoformans Z-2901) [Search protein sequence]

ARQNLKSTDRAVQQMLDKAKREGIQTVWDRYEAMKPQCGFGETGLCCRHC
LQGPCRINPFGDEPKVGICGATAEVIVARGLDRSIAAGAAGHSGHAKHLA
HTLKKAVQGKAASYMIKDRTKLHSIAKRLGIPTEGQKDEDIALEVAKAAL
ADFHEKDTPVLWVTTVLPPSRVKVLSAHGLIPAGIDHEIAEIMHRTSMGC
DADAQNLLLGGLRCSLADLAGCYMGTDLADILFGTPAPVVTESNLGVLKA
DAVNVAVHGHNPVLSDIIVSVSKEMENEARAAGATGINVVGICCTGNEVL
MRHGIPACTHSVSQEMAMITGALDAMILDYQCIQPSVATIAECTGTTVIT
TMEMSKITGATHVNFAEEAAVENAKQILRLAIDTFKRRKGKPVEIPNIKT
KVVAGFSTEAIINALSKLNANDPLKPLIDNVVNGNIRGVCLFAGCNNVKV
PQDQNFTTIARKLLKQNVLVVATGCGAGALMRHGFMDPANVDELCGDGLK
AVLTAIGEANGLGGPLPPVLHMGSCVDNSRAVALVAALANRLGVDLDRLP
VVASAAEAMHEKAVAIGTWAVTIGLPTHIGVLPPITGSLPVTQILTSSVK
DITGGYFIVELDPETAADKLLAAINERRAGLGLPW

3D structure

PDB

3i39 Structural basis of cyanide inhibition of Ni, Fe-containing carbon monoxide dehydrogenase

Chain

Resolution

1.36 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

1.2.7.4: anaerobic carbon-monoxide dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	SF4	X	C48 H50 C51 G54 C56 I69 C70 R80 M199	C47 H49 C50 G53 C55 I68 C69 R79 M198
BS02	FES	X	C39 F41 G42 C47	C38 F40 G41 C46
BS03	WCC	X	H261 C294 C295 S312 C333 G445 C446 C476 C526 K563	H260 C293 C294 S311 C332 G444 C445 C475 C525 K562
BS04	FE2	X	H261 C295 C526	H260 C294 C525
BS05	FE2	X	H261 C295 C526	H260 C294 C525
BS06	CYN	X	H93 C526 K563	H92 C525 K562

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0004601	peroxidase activity
GO:0016151	nickel cation binding
GO:0016491	oxidoreductase activity
GO:0043885	anaerobic carbon-monoxide dehydrogenase activity
GO:0046872	metal ion binding
GO:0050418	hydroxylamine reductase activity
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:0006091	generation of precursor metabolites and energy
GO:0042542	response to hydrogen peroxide
GO:0098869	cellular oxidant detoxification

	Cellular Component
GO:0005737	cytoplasm
GO:0005886	plasma membrane

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:3i39, PDBe:3i39, PDBj:3i39
PDBsum	3i39
PubMed	19583208
UniProt	Q9F8A8\|COOS2_CARHZ Carbon monoxide dehydrogenase 2 (Gene Name=cooS2)

[Back to BioLiP]