Structure of PDB 3h1v Chain X

Receptor sequence
>3h1vX (length=446) Species: 9606 (Homo sapiens) [Search protein sequence]
MVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRS
TPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDA
MTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGIL
LNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCY
YEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSG
ELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENL
LFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDC
DIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYK
LHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA
3D structure
PDB3h1v The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators.
ChainX
Resolution2.11 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R85 S151
Catalytic site (residue number reindexed from 1) R71 S137
Enzyme Commision number 2.7.1.1: hexokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC X S151 F152 T168 K169 N204 D205 I225 N231 E256 E290 S137 F138 T154 K155 N190 D191 I211 N217 E242 E276
BS02 TK1 X Y61 R63 G97 Q98 I211 Y214 Y215 V455 Y47 R49 G83 Q84 I197 Y200 Y201 V441
Gene Ontology
Molecular Function
GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005536 D-glucose binding
GO:0008865 fructokinase activity
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019158 mannokinase activity
GO:0141089 glucose sensor activity
Biological Process
GO:0001678 intracellular glucose homeostasis
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006007 glucose catabolic process
GO:0006096 glycolytic process
GO:0006110 regulation of glycolytic process
GO:0006739 NADP metabolic process
GO:0009749 response to glucose
GO:0016310 phosphorylation
GO:0019318 hexose metabolic process
GO:0032024 positive regulation of insulin secretion
GO:0032869 cellular response to insulin stimulus
GO:0042593 glucose homeostasis
GO:0043266 regulation of potassium ion transport
GO:0044320 cellular response to leptin stimulus
GO:0045721 negative regulation of gluconeogenesis
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046835 carbohydrate phosphorylation
GO:0050796 regulation of insulin secretion
GO:0051156 glucose 6-phosphate metabolic process
GO:0061621 canonical glycolysis
GO:0070509 calcium ion import
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3h1v, PDBe:3h1v, PDBj:3h1v
PDBsum3h1v
PubMed19736020
UniProtP35557|HXK4_HUMAN Hexokinase-4 (Gene Name=GCK)

[Back to BioLiP]