Structure of PDB 3gws Chain X

Receptor sequence
>3gwsX (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
EELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIG
VDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIM
SLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSF
NLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHV
THFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE
3D structure
PDB3gws Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function
ChainX
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T3 X F272 I276 A279 R282 M310 M313 R316 L330 N331 L346 H435 F455 F59 I63 A66 R69 M97 M100 R103 L117 N118 L133 H221 F241 PDBbind-CN: -logKd/Ki=10.09,Kd=0.081nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3gws, PDBe:3gws, PDBj:3gws
PDBsum3gws
PubMed16781732
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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