Structure of PDB 3g90 Chain X

Receptor sequence
>3g90X (length=345) Species: 9606 (Homo sapiens) [Search protein sequence]
NQFYSVEVGDSTFTVLKRYQNLKPIGSQGIVCAAYDAVLDRNVAIKKLSR
PFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME
LMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV
KSDCTLKILDFGLASFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCI
MGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP
KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD
ALQHPYINVWYDPAEVEAPPPQIQLDEREHTIEEWKELIYKEVMN
3D structure
PDB3g90 Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors.
ChainX
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N194 D207
Catalytic site (residue number reindexed from 1) N147 D160
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J72 X I70 V78 E147 M149 D150 A151 N152 V196 L206 I25 V31 E100 M102 D103 A104 N105 V149 L159 MOAD: Ki=0.44uM
PDBbind-CN: -logKd/Ki=6.36,Ki=0.44uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3g90, PDBe:3g90, PDBj:3g90
PDBsum3g90
PubMed19361991
UniProtP53779|MK10_HUMAN Mitogen-activated protein kinase 10 (Gene Name=MAPK10)

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