Structure of PDB 3fyk Chain X

Receptor sequence
>3fykX (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
QFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM
LQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGG
ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLY
TSKRPNAILKLTDFGFAKETTSKYDKSCDMWSLGVIMYILLCGYPPFYSG
QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP
QTPLHTSRVLKEDKERWEDVKEEMTSALATMR
3D structure
PDB3fyk Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency.
ChainX
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N191 D207
Catalytic site (residue number reindexed from 1) N147 D163
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B98 X G71 G73 A91 K93 M138 L141 T206 D207 G27 G29 A47 K49 M94 L97 T162 D163 PDBbind-CN: -logKd/Ki=7.40,IC50=0.04uM
BindingDB: IC50=5nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3fyk, PDBe:3fyk, PDBj:3fyk
PDBsum3fyk
PubMed19616942
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

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