Structure of PDB 3fyj Chain X

Receptor sequence
>3fyjX (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
QFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM
LQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGG
ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLY
TSKRPNAILKLTDFGFAKETTSKYDKSCDMWSLGVIMYILLCGYPPFYSG
QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP
QTPLHTSRVLKEDKERWEDVKEEMTSALATMR
3D structure
PDB3fyj Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency.
ChainX
Resolution3.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) N191 D207
Catalytic site (residue number reindexed from 1) N147 D163
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B97 X L70 G71 V78 C140 L141 D142 N191 T206 D207 L26 G27 V34 C96 L97 D98 N147 T162 D163 PDBbind-CN: -logKd/Ki=8.30,IC50=5nM
BindingDB: IC50=201nM,Ki=5.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3fyj, PDBe:3fyj, PDBj:3fyj
PDBsum3fyj
PubMed19616942
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

[Back to BioLiP]