Structure of PDB 3cr5 Chain X

Receptor sequence
>3cr5X (length=91) Species: 9913 (Bos taurus) [Search protein sequence]
MSELEKAVVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKE
QEVVDKVMETLDSDGDGECDFQEFMAFVAMITTACHEFFEH
3D structure
PDB3cr5 Divalent metal ion complexes of S100B in the absence and presence of pentamidine.
ChainX
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PNT X C84 F88 C85 F89 MOAD: Kd=64uM
PDBbind-CN: -logKd/Ki=4.19,Kd=64uM
BS02 PNT X F43 C84 F87 F88 F44 C85 F88 F89 MOAD: Kd=64uM
PDBbind-CN: -logKd/Ki=4.19,Kd=64uM
BS03 ZN X H15 H25 H16 H26
BS04 CA X S18 E21 D23 K26 E31 S19 E22 D24 K27 E32
BS05 CA X D61 D63 D65 E67 E72 D62 D64 D66 E68 E73
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019210 kinase inhibitor activity
GO:0042803 protein homodimerization activity
GO:0044548 S100 protein binding
GO:0046872 metal ion binding
GO:0048156 tau protein binding
GO:0048306 calcium-dependent protein binding
GO:0050786 RAGE receptor binding
Biological Process
GO:0006417 regulation of translation
GO:0007155 cell adhesion
GO:0007409 axonogenesis
GO:0007611 learning or memory
GO:0008284 positive regulation of cell population proliferation
GO:0016310 phosphorylation
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0045917 positive regulation of complement activation
GO:0048143 astrocyte activation
GO:0071638 negative regulation of monocyte chemotactic protein-1 production
GO:0097490 sympathetic neuron projection extension
GO:1990845 adaptive thermogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:3cr5, PDBe:3cr5, PDBj:3cr5
PDBsum3cr5
PubMed18602402
UniProtP02638|S100B_BOVIN Protein S100-B (Gene Name=S100B)

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