Structure of PDB 3a4o Chain X

Receptor sequence
>3a4oX (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
DAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAF
LEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGG
KVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFG
LARVEGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPG
RTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSV
LDDFYTATE
3D structure
PDB3a4o Structural basis for the inhibitor recognition of human Lyn kinase domain
ChainX
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N141 D154
Catalytic site (residue number reindexed from 1) N135 D148
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU X L22 V30 K44 E89 Y90 M91 G94 A140 L143 L16 V24 K38 E83 Y84 M85 G88 A134 L137 PDBbind-CN: -logKd/Ki=8.89,IC50=1.3nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3a4o, PDBe:3a4o, PDBj:3a4o
PDBsum3a4o
PubMed19857964
UniProtP07948|LYN_HUMAN Tyrosine-protein kinase Lyn (Gene Name=LYN)

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