Structure of PDB 2yiv Chain X

Receptor sequence

>2yivX (length=635) Species: 129958 (Carboxydothermus hydrogenoformans)

ARQNLKSTDRAVQQMLDKAKREGIQTVWDRYEAMKPQCGFGETGLCCRHC
LQGPCRINPFGDEPKVGICGATAEVIVARGLDRSIAAGAAGHSGHAKHLA
HTLKKAVQGKAASYMIKDRTKLHSIAKRLGIPTEGQKDEDIALEVAKAAL
ADFHEKDTPVLWVTTVLPPSRVKVLSAHGLIPAGIDHEIAEIMHRTSMGC
DADAQNLLLGGLRCSLADLAGCYMGTDLADILFGTPAPVVTESNLGVLKA
DAVNVAVHGHNPVLSDIIVSVSKEMENEARAAGATGINVVGICCTGNEVL
MRHGIPACTHSVSQEMAMITGALDAMILDYQCIQPSVATIAECTGTTVIT
TMEMSKITGATHVNFAEEAAVENAKQILRLAIDTFKRRKGKPVEIPNIKT
KVVAGFSTEAIINALSKLNANDPLKPLIDNVVNGNIRGVCLFAGCNNVKV
PQDQNFTTIARKLLKQNVLVVATGCGAGALMRHGFMDPANVDELCGDGLK
AVLTAIGEANGLGGPLPPVLHMGSCVDNSRAVALVAALANRLGVDLDRLP
VVASAAEAMHEKAVAIGTWAVTIGLPTHIGVLPPITGSLPVTQILTSSVK
DITGGYFIVELDPETAADKLLAAINERRAGLGLPW

3D structure

• PDB: 2yiv N-Butyl Isocyanide Oxidation at the [Nife4S4Oh(X)] Cluster of Co Dehydrogenase.
• Chain: X
• Resolution: 1.28 Å

Enzymatic activity

• Enzyme Commision number: 1.2.7.4: anaerobic carbon-monoxide dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	X	C48 H50 C51 G54 C56 I69 C70 R80 M199	C47 H49 C50 G53 C55 I68 C69 R79 M198
BS02	FES	X	C39 G42 C47	C38 G41 C46
BS03	WCC	X	H261 C294 C295 S312 C333 G445 C446 C476 C526 K563	H260 C293 C294 S311 C332 G444 C445 C475 C525 K562
BS04	YIV	X	H93 A444 G445 C526 K563 A564 I567	H92 A443 G444 C525 K562 A563 I566
BS05	FE	X	H261 C295 C526	H260 C294 C525
BS06	NBN	X	L82 V565 I586 F608	L81 V564 I585 F607	PDBbind-CN: -logKd/Ki=2.78,Ki=1.66mM

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004601 peroxidase activity
• GO:0016151 nickel cation binding
• GO:0016491 oxidoreductase activity
• GO:0043885 anaerobic carbon-monoxide dehydrogenase activity
• GO:0046872 metal ion binding
• GO:0050418 hydroxylamine reductase activity
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0006091 generation of precursor metabolites and energy
• GO:0042542 response to hydrogen peroxide
• GO:0098869 cellular oxidant detoxification

Cellular Component

• GO:0005737 cytoplasm
• GO:0005886 plasma membrane

External links

• PDB: RCSB:2yiv, PDBe:2yiv, PDBj:2yiv
• PDBsum: 2yiv
• PubMed: 21904889
• UniProt: Q9F8A8|COOS2_CARHZ Carbon monoxide dehydrogenase 2 (Gene Name=cooS2)