Structure of PDB 2poq Chain X

Receptor sequence
>2poqX (length=331) Species: 9541 (Macaca fascicularis) [Search protein sequence]
ALRWGIVSVGLISSDFTAVLQTLPRSEHQVVAVAARDLSRAKEFAQKHDI
PKAYGSYEELAKDPNVEVAYVGTQHPQHKAAVMLCLAAGKAVLCEKPMGV
NAAEVREMVTEARSRGLFLMEAIWTRFFPASEALRSVLAQGTLGDLRVAR
AEFGKNLTHVPRAVDWAQAGGALLDLGIYCVQFISMVFGGQKPEKISVMG
RRHETGVDDTVTVLLQYPGEVHGSFTCSITAQLSNTASVSGTKGMAQLLN
PCWCPTELVVKGEHKEFLLPPVPKNCNFDNGAGMSYEAKHVRECLRKGLK
ESPVIPLVESELLADILEEVRRAIGVTFPQD
3D structure
PDB2poq Structure of monkey dimeric dihydrodiol dehydrogenase in complex with isoascorbic acid.
ChainX
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.179: D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming).
1.3.1.20: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ISD X K1156 F1279 D1280 K155 F278 D279 PDBbind-CN: -logKd/Ki=4.42,IC50=38uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO:0047837 D-xylose 1-dehydrogenase (NADP+) activity
Biological Process
GO:0042843 D-xylose catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2poq, PDBe:2poq, PDBj:2poq
PDBsum2poq
PubMed18453689
UniProtQ9TQS6|DHDH_MACFA Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (Gene Name=DHDH)

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