Structure of PDB 2h7f Chain X

Receptor sequence
>2h7fX (length=314) Species: 10255 (Variola virus) [Search protein sequence]
MRALFYKDGKLFTDNNFLNPVSDNNPAYEVLQHVKIPTHLTDVVVYGQTW
EEALTRLIFVGSDSKGRRQYFYGKMHVQNRNAKRDRIFVRVYNVMKRINS
FINKNIKKSSTDSNYQLAVFMLMETMFFIRFGKMKYLKENETVGLLTLKN
KHIEISPDKIVIKFVGKDKVSHEFVVHKSNRLYKPLLKLTDDSSPEEFLF
NKLSERKVYESIKQFGIRIKDLRTYGVNYTFLYNFWTNVKSISPLPSPKK
LIALTIKQTAEVVGHTPSISKRAYMATTILEMVKDKNFLDVVSKTTFDEF
LSIVVDHVKSSTDG
3D structure
PDB2h7f Structural basis for specificity in the poxvirus topoisomerase.
ChainX
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R130
Catalytic site (residue number reindexed from 1) R130
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna X Y70 Y72 R80 R206 K220 A273 Y274 Y70 Y72 R80 R206 K220 A273 Y274
BS02 dna X H39 R67 Q69 R130 F131 G132 K133 Y136 N140 T142 K167 D168 K220 H39 R67 Q69 R130 F131 G132 K133 Y136 N140 T142 K167 D168 K220
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2h7f, PDBe:2h7f, PDBj:2h7f
PDBsum2h7f
PubMed16885024
UniProtP32989|TOP1_VAR67 DNA topoisomerase 1 (Gene Name=OPG111)

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