Structure of PDB 2dq7 Chain X

Receptor sequence
>2dq7X (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPES
FLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFG
LARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELV
TKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEER
PTFEYLQSFLEDY
3D structure
PDB2dq7 Structure of human Fyn kinase domain complexed with staurosporine.
ChainX
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N135 D148
Catalytic site (residue number reindexed from 1) N135 D148
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU X L17 V25 A37 K39 T82 Y84 M85 G88 A134 L137 D148 L17 V25 A37 K39 T82 Y84 M85 G88 A134 L137 D148 PDBbind-CN: -logKd/Ki=8.32,IC50=4.8nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2dq7, PDBe:2dq7, PDBj:2dq7
PDBsum2dq7
PubMed16782058
UniProtP06241|FYN_HUMAN Tyrosine-protein kinase Fyn (Gene Name=FYN)

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