Structure of PDB 2dew Chain X

Receptor sequence
>2dewX (length=629) Species: 9606 (Homo sapiens) [Search protein sequence]
QGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPCTSFSINASPGVVVDITW
PLDPGVEVTLTMKAASGSTGDQKVQISYYGPKTPPVKALLYLTAVEISLC
ADITRTGKQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDL
QDMSLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATCSVVLGPKWP
SHYLMVPGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVV
FQDSVVFRVAPWIMTPNTQPPQEVYACSIFENEDFLKSVTTLAMKAKCKL
TICPEEENMDDQWMQDEMEIGYIQAPHKTLPVVFDSPRNRGLKEFPIKRV
MGPDFGYVTRGPQTGGISGLDSFGNLEVSPPVTVRGKEYPLGRILFGDSC
YPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDR
KGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKT
LREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFP
NMVNMLVLGKHLGIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFF
TYHIRHGEVHAGTNVRRKPFSFKWWNMVP
3D structure
PDB2dew Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4
ChainX
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.3.15: protein-arginine deiminase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0140794 histone arginine deiminase activity
GO:0140795 histone H3R2 arginine deiminase activity
GO:0140796 histone H3R8 arginine deiminase activity
GO:0140797 histone H3R17 arginine deiminase activity
GO:0140798 histone H3R26 arginine deiminase activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006338 chromatin remodeling
GO:0019827 stem cell population maintenance
GO:0036211 protein modification process
GO:0043687 post-translational protein modification
GO:0045087 innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2dew, PDBe:2dew, PDBj:2dew
PDBsum2dew
PubMed16567635
UniProtQ9UM07|PADI4_HUMAN Protein-arginine deiminase type-4 (Gene Name=PADI4)

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