Structure of PDB 2c01 Chain X

Receptor sequence
>2c01X (length=135) Species: 9606 (Homo sapiens) [Search protein sequence]
MKPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFA
NVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYA
QTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII
3D structure
PDB2c01 Crystal Structures of Eosinophil-Derived Neurotoxin (Edn) in Complex with the Inhibitors 5'- ATP, Ap(3)A, Ap(4)A, and Ap(5)A.
ChainX
Resolution1.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP X Q14 H15 K38 R68 N70 A110 V128 H129 L130 Q15 H16 K39 R69 N71 A111 V129 H130 L131 MOAD: Ki=21uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:2c01, PDBe:2c01, PDBj:2c01
PDBsum2c01
PubMed16401072
UniProtP10153|RNAS2_HUMAN Non-secretory ribonuclease (Gene Name=RNASE2)

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