Structure of PDB 2bq8 Chain X

Receptor sequence
>2bq8X (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]
ATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGD
NFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQI
AYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQ
PERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLV
KQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSKRHQ
RKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLFKTRLPR
RARP
3D structure
PDB2bq8 Crystal Structures of Recombinant Human Purple Acid Phosphatase with and without an Inhibitory Conformation of the Repression Loop.
ChainX
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.2: acid phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 X D12 D50 Y53 D145 H221 D12 D50 Y53 D145 H221
BS02 FE2 X D50 D145 H184 H219 D50 D145 H184 H219
BS03 ZN X E67 D71 E67 D71
Gene Ontology
Molecular Function
GO:0003993 acid phosphatase activity
GO:0008198 ferrous iron binding
GO:0008199 ferric iron binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006809 nitric oxide biosynthetic process
GO:0010936 negative regulation of macrophage cytokine production
GO:0032496 response to lipopolysaccharide
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032695 negative regulation of interleukin-12 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032929 negative regulation of superoxide anion generation
GO:0034097 response to cytokine
GO:0042554 superoxide anion generation
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045453 bone resorption
GO:0050728 negative regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
GO:0060349 bone morphogenesis
Cellular Component
GO:0005764 lysosome
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2bq8, PDBe:2bq8, PDBj:2bq8
PDBsum2bq8
PubMed15993892
UniProtP13686|PPA5_HUMAN Tartrate-resistant acid phosphatase type 5 (Gene Name=ACP5)

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