Structure of PDB 1pcj Chain X

Receptor sequence
>1pcjX (length=458) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
APTLPASIFRAYDIRGVVGDTLTAETAYWIGRAIGSESLARGEPCVAVGR
DGRLSGPELVKQLIQGLVDCGCQVSDVGMVPTPVLYYAANVLEGKSGVML
TGSHNPPDYNGFKIVVAGETLANEQIQALRERIEKNDLASGVGSVEQVDI
LPRYFKQIRDDIAMAKPMKVVVDCGNGVAGVIAPQLIEALGCSVIPLYCE
VDGNFPNHHPDPGKPENLKDLIAKVKAENADLGLAFDGDGDRVGVVTNTG
TIIYPDRLLMLFAKDVVSRNPGADIIFDVKCTRRLIALISGYGGRPVMWK
TGHSLIKKKMKETGALLAGEMSGHVFFKERWFGFDDGIYSAARLLEILSQ
DQRDSEHVFSAFPSDISTPEINITVTEDSKFAIIEALQRDAQWGEGNITT
LDGVRVDYPKGWGLVRASNTTPVLVLRFEADTEEELERIKTVFRNQLKAV
DSSLPVPF
3D structure
PDB1pcj Structural basis of diverse substrate recognition by the enzyme PMM/PGM from P. aeruginosa.
ChainX
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R20 S108 H109 K118 D242 D244 D246 R247 H329 D340
Catalytic site (residue number reindexed from 1) R15 S103 H104 K113 D237 D239 D241 R242 H324 D335
Enzyme Commision number 5.4.2.2: phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
5.4.2.8: phosphomannomutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M1P X Y17 S108 T306 G307 E325 S327 H329 R421 S423 N424 T425 Y12 S103 T301 G302 E320 S322 H324 R416 S418 N419 T420
BS02 ZN X S108 D242 D244 D246 S103 D237 D239 D241
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004614 phosphoglucomutase activity
GO:0004615 phosphomannomutase activity
GO:0016853 isomerase activity
GO:0016868 intramolecular phosphotransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009243 O antigen biosynthetic process
GO:0009244 lipopolysaccharide core region biosynthetic process
GO:0009298 GDP-mannose biosynthetic process
GO:0042121 alginic acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1pcj, PDBe:1pcj, PDBj:1pcj
PDBsum1pcj
PubMed14725765
UniProtP26276|ALGC_PSEAE Phosphomannomutase/phosphoglucomutase (Gene Name=algC)

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