Structure of PDB 1fm6 Chain X

Receptor sequence
>1fm6X (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSL
MMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPG
FVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKS
LRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKP
IEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQV
IKKTETDMSLHPLLQEIYKDLY
3D structure
PDB1fm6 Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.
ChainX
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide X K301 L311 N312 Q314 V315 K319 L468 E471 K474 K96 L106 N107 Q109 V110 K114 L263 E266 K269
BS02 BRL X F282 G284 C285 S289 H323 I341 M364 H449 Y473 F77 G79 C80 S84 H118 I136 M159 H244 Y268 BindingDB: EC50=40nM,IC50=1.000000nM,Ki=8nM,Kd=0.145000nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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External links
PDB RCSB:1fm6, PDBe:1fm6, PDBj:1fm6
PDBsum1fm6
PubMed10882139
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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