Structure of PDB 8wdk Chain W

Receptor sequence

>8wdkW (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]

SRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQN
ALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENY
RIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNA
ASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENY
THLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEF
TELLKVMIHPDPERRPSAMALVKHSVL

3D structure

PDB

8wdk Structure of Cul2-VCB-Protac-Wee1 complex at 3.6 Angstrom resolution.

Chain

Resolution

3.64 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	W6U	W	I305 V313 K328 C379 G382 F433	I13 V21 K36 C87 G90 F141

External links

PDB	RCSB:8wdk, PDBe:8wdk, PDBj:8wdk
PDBsum	8wdk
PubMed
UniProt	P30291\|WEE1_HUMAN Wee1-like protein kinase (Gene Name=WEE1)

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