Structure of PDB 8rch Chain W

Receptor sequence

>8rchW (length=428) Species: 9606 (Homo sapiens) [Search protein sequence]

TVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANL
QKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVP
RPTVNGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSF
KQFALQREQELEVSMKNCIQLAACEATELLPMIPDLPADLFTSCLTTPIK
IALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDT
IAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPP
TYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTM
GVENRNPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGI
FPYVLKLLQSSARELRPLLVFIWAKILA

3D structure

PDB

8rch cryoEM structure of mTORC1 with the cancer-associated 1455-EWED-1458 duplication variant, overall refinement

Chain

Resolution

4.0 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	W	T317 Q438 L441 S442 Y475 K478 L479	T245 Q366 L369 S370 Y403 K406 L407

External links

PDB	RCSB:8rch, PDBe:8rch, PDBj:8rch
PDBsum	8rch
PubMed
UniProt	Q8N122\|RPTOR_HUMAN Regulatory-associated protein of mTOR (Gene Name=RPTOR)

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