Structure of PDB 8ipx Chain W

Receptor sequence
>8ipxW (length=388) Species: 9606 (Homo sapiens) [Search protein sequence]
FRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTET
PHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAG
HSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQ
SVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALST
DYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSG
SDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIK
LWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQK
LAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR
3D structure
PDB8ipx Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
ChainW
Resolution4.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna W W158 R237 W61 R140
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0000278 mitotic cell cycle
GO:0001756 somitogenesis
GO:0001822 kidney development
GO:0001826 inner cell mass cell differentiation
GO:0007219 Notch signaling pathway
GO:0042273 ribosomal large subunit biogenesis
GO:0045930 negative regulation of mitotic cell cycle
GO:0048705 skeletal system morphogenesis
GO:0061484 hematopoietic stem cell homeostasis
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ipx, PDBe:8ipx, PDBj:8ipx
PDBsum8ipx
PubMed37491604
UniProtQ9NVX2|NLE1_HUMAN Notchless protein homolog 1 (Gene Name=NLE1)

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