Structure of PDB 8etu Chain W

Receptor sequence
>8etuW (length=442) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
SLIAAHSHITGLGLDENLQPRPTSEGMVGQLQARRAAGVILKMVQNGTIA
GRAVLVAGPPSTGKTALAMGVSQSLGKDVPFTAIAGSEIFSLELSKTEAL
TQAFRKSIGIKIKEETELIEGEVVEIQIDRSITGGHKQGKLTIKTTDMET
IYELGNKMIDGLTKEKVLAGDVISIDKASGKITKLGRSFARSRDYDAMGA
DTRFVQCPEGELQKRKTVVHTVSLHEIDVINSRTQGFLALFTGDTGEIRS
EVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSFINRALEDEF
APIVMMATNRGVSKTRGTNYKSPHGLPLDLLDRSIIITTKSYNEQEIKTI
LSIRAQEEEVELSSDALDLLTKTGVETSLRYSSNLISVAQQIAMKRKNNT
VEVEDVKRAYLLFLDSARSVKYVQENESQYIDDQGNVQISIA
3D structure
PDB8etu Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility.
ChainW
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide W E142 I143 Q144 I145 D146 R147 Q155 G156 I168 A186 F206 R208 E125 I126 Q127 I128 D129 R130 Q138 G139 I151 A169 F189 R191
BS02 ADP W H23 H25 G43 M44 P77 S78 T79 G80 K81 T82 Y359 I367 R397 H6 H8 G26 M27 P60 S61 T62 G63 K64 T65 Y342 I350 R380
Gene Ontology
Molecular Function
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
GO:0043139 5'-3' DNA helicase activity
Biological Process
GO:0000492 box C/D snoRNP assembly
GO:0006281 DNA repair
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006364 rRNA processing
GO:0032508 DNA duplex unwinding
GO:0050821 protein stabilization
Cellular Component
GO:0000785 chromatin
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0031011 Ino80 complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0097255 R2TP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8etu, PDBe:8etu, PDBj:8etu
PDBsum8etu
PubMed37384669
UniProtQ12464|RUVB2_YEAST RuvB-like protein 2 (Gene Name=RVB2)

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