Structure of PDB 7r43 Chain W

Receptor sequence
>7r43W (length=114) Species: 9913 (Bos taurus) [Search protein sequence]
TSVKPIFSRDMNEAKRRVRELYRAWYREVPNTVHLFQLDISVKQGRDKVR
EMFKKNAHITDPRVVDLLVIKGKMELEETIKVWKQRTHVMRFFHETEAPR
PKDFLSKFYVGHDP
3D structure
PDB7r43 Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.
ChainW
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EHZ W K29 V32 F67 N70 A71 L82 F106 K15 V18 F53 N56 A57 L68 F92
Gene Ontology
Biological Process
GO:0006979 response to oxidative stress
GO:0032981 mitochondrial respiratory chain complex I assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045271 respiratory chain complex I

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Biological Process
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Cellular Component
External links
PDB RCSB:7r43, PDBe:7r43, PDBj:7r43
PDBsum7r43
PubMed36701435
UniProtQ02366|NDUA6_BOVIN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (Gene Name=NDUFA6)

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